TSPYL2 and learning disability: Consistent with a possible role for Tspyl2 pathways in neurodevelopment, Xp11.2 microduplication incorporating the TSPYL2 locus has been reported in male patients with ADHD (Moey et al. 2015); human TSPYL2 is close to ALAS2, a marker linked to schizophrenia in a linkage study of 34 families (Dann et al. 1997); and mutations in CASK are linked to learning disability (Hackett et al. 2010; Tarpey et al. 2009).