Recently, it has been reported that sex hormone binding globulin (SHBG) and vitamin D are 2 novel factors associated with NAFLD, diabetes, and cardiovascular disease.5–8 Vitamin D exerts a classical function on calcium/phosphorus homeostasis, but it has also been reported to affect the function of the immune system, cell differentiation and proliferation, etc.6 Vitamin D deficiency is often found together with NAFLD, and this finding is not unexpected because it may influence NAFLD through mechanisms such as hepatic endotoxin exposure and profibrotic effects.9 The gene discussed is SHBG; the disease is metabolic dysfunction-associated steatotic liver disease.