After being secreted into the blood, it binds sex hormones, transports them to target tissues and regulates their biological activities.7 Recent novel insights indicate that a reduction in SHBG level seems to be the convergence of crosstalk among inflammation, diabetes, obesity, and the risk for cardiovascular diseases.7 Furthermore, in 1 national study, men in the high tertile of SHBG were 54% less likely to have NAFLD than in the lowest tertile.5 It also has been noted that liver fat but not total body or visceral fat is significantly associated with SHBG levels.10 This evidence concerns the gene SHBG and obesity due to melanocortin 4 receptor deficiency.