SHBG and cardiovascular disorder: Recently, it has been reported that sex hormone binding globulin (SHBG) and vitamin D are 2 novel factors associated with NAFLD, diabetes, and cardiovascular disease.5–8 Vitamin D exerts a classical function on calcium/phosphorus homeostasis, but it has also been reported to affect the function of the immune system, cell differentiation and proliferation, etc.6 Vitamin D deficiency is often found together with NAFLD, and this finding is not unexpected because it may influence NAFLD through mechanisms such as hepatic endotoxin exposure and profibrotic effects.9