This indicate that SHBG may have a greater impact on this association than 25(OH)D, which is in agreement with a previous comment that “the crosstalk between inflammation, T2D, sex steroids, and the risk for CVD seems to converge on a reduction in the levels of SHBG.”7 NAFLD may also be added to this crosstalk. The gene discussed is SHBG; the disease is type 2 diabetes mellitus.