MUC5AC and pancreatic adenocarcinoma: It has been reported that the voxel with low ADC value is well correlated with highly cellular components within the tumor, whereas the higher frequency of voxels with high ADC values reflects mucin or necrotic components.18,21,34 The loose fibrosis within pancreatic adenocarcinoma may account for the freedom of diffusion of water molecules and high ADC values, while dense fibrosis may restrict water diffusion, resulting in lower ADC values.13 Therefore, the ADC histogram parameters can reflect pathologic features of pancreatic adenocarcinoma and neuroendocrine tumor.