Furthermore, when stratified by clinico-pathological parameters of breast cancer, there were no associations between Leptin (-2548G/A) genes and the parameters in the dominant model, such as menopausal status (OR = 0.17; 95% CI = 0.14–0.20; P = 0.06), clinical stage (OR = 0.24; 95% CI = 0.17–0.33; P = 0.21), ER/PR receptor (OR = 0.30; 95% CI = 0.22–0.41; P = 0.15), and lymph nodes (OR = 0.39; 95% CI = 0.28–0.53; P = 0.32). This evidence concerns the gene LEP and breast cancer.