The results showed (Figure 3) that the Leptin (-2548G/A) gene polymorphism was associated with breast cancer risk in 3 genotypes (A vs G: OR = 1.11, 95%CI = 1.03–1.20, P = 0.006, Phet = 0.00001; AA vs GG: OR = 1.21, 95%CI = 1.04–1.41, P = 0.01, Phet = 0.001; AA + GA vs GG: OR = 0.69, 95%CI = 0.62–0.77, P < 0.00001, Phet = 0.00001), but no associations in other genetic models (GA vs GG: OR = 0.95, 95% CI = 0.84–1.07, P = 0.41, Phet = 0.70; AA vs GA + GG: OR = 1.12, 95% CI = 0.99–1.27, P = 0.08, Phet = 0.00001). Here, LEP is linked to breast cancer.