However, there were no significant associations between the Leptin (-2548G/A) gene polymorphism and breast cancer risk in other genotype distributions (GA vs GG: OR = 0.99, 95%CI = 0.88 − 1.11, P = 0.88, Phet = 0.39; AA vs GA + GG: OR = 1.12, 95%CI = 1.00 − 1.27, P = 0.06, Phet = 0.00001). This evidence concerns the gene LEP and breast carcinoma.