Dys-regulated Wnt signalling has also been suggested to underlie many neurological conditions including Alzheimer’s disease (Sadigh-Eteghad et al. 2015), autism and schizophrenia (reviewed in Berwick and Harvey 2014), and abnormal CDK5 signaling has a role in the pathogenesis of various neurodegenerative disorders including Parkinson’s and Alzheimer’s diseases, disrupting proteins including α-synuclein (ASN) and β-amyloid peptide (Aβ) (Wilkaniec et al. 2015). This evidence concerns the gene CDK5 and early-onset autosomal dominant Alzheimer disease.