CD4 and atopic eczema: From histological findings that the majority of skin-infiltrating T cells in active atopic dermatitis lesions in humans are CD4+ T cells, CD4+ T cells are considered pivotal to the development of eczema and skin eosinophilic inflammation, because they produce a mixed pattern of Th1 and Th2 cytokines in the pathological development of atopic dermatitis [26].