In our K. pneumoniae pneumonia model, RAGE-/- mice had higher levels of the chemokines KC and MCP-1 in their lung homogenates and increased circulating IL-10 concentrations compared to wild-type mice 48 hours after infection, while intranasal inoculation with LPS from K. pneumoniae did not lead to higher broncho-alveolar chemokine levels in the RAGE-/- mice. The gene discussed is CALCA; the disease is infection.