Capillary/myocyte mismatch is a hallmark of maladaptive myocardial hypertrophy, and increased VEGF expression is involved in preservation of the density of myocardial capillaries in cardiac hypertrophy and prevention of the development of maladaptive ventricular remodeling [58], showing that VEGF down-regulation is regarded as a maladaptive response in RVH. The gene discussed is VEGFA; the disease is cardiac hypertrophy.