To find causal underpinnings for the obesity induction, we intersected RNA-sequencing datasets comparing epididymal adipose tissue gene expression in our obese- and lean-Trim28+/D9 animals with comparable data contrasting high-fat diet (HFD)-induced obese animals with chow-fed controls (GSE38337). This evidence concerns the gene TRIM28 and obesity due to melanocortin 4 receptor deficiency.