INSR and myotonic dystrophy type 1: Importantly, although Stau1 overexpression in DM1 myoblasts did rescue splicing patterns of many pre-mRNAs towards WT, as previously observed for INSR exon 11, a number of Stau1-induced splicing changes were also found shifting away from WT patterns, and thus would be predicted to exacerbate the DM1 pathology.