For example, in a Drosophila DM1 model the RNA-binding proteins TBPH (homolog of human TAR DNA-binding protein 43 or TDP-43) and BSF (Bicoid stability factor; homolog of human LRPPRC) were found be misregulated with the expression of CUG expansions resulting in altered muscle sarcomere location of these proteins [59]. This evidence concerns the gene LRPPRC and myotonic dystrophy type 1.