Our data suggest that BMP-7 has the potential to inhibit the pro-inflammatory response that is persistent in ATH through enhanced M2 macrophage differentiation and associated anti-inflammatory mediators as previously evidenced in in vitro and in vivo models including pre-diabetic cardiomyopathy and inflammatory arthritis [9, 32, 33]. The gene discussed is BMP7; the disease is diabetic cardiomyopathy.