Next we examined the other integrin binding proteins ICAP-1, ITGB1, and CIB1 in WISP-1 promoting VEGF-C secretion, the results found that infection with ICAP-1, ITGB1, and CIB1 shRNA also reduced WISP-1-promoted VEGF-C expression, implying these integrin binding proteins also involved in WISP-1-promoted VEGF-C production (Supplementary Figure S4). The gene discussed is VEGFC; the disease is infection.