Thus, we had four melanoma patient-derived populations with different characteristics: (1) DMBC17: BRAFWT, MITF-Mhigh, slow-cycling, highly differentiated, (2) DMBC21: BRAFV600E, MITF-Mhigh, slow-cycling, highly differentiated and (3,4) DMBC11 and DMBC12: BRAFV600E, MITF-Mlow, fast-cycling, less differentiated. Here, MITF is linked to melanoma.