Moreover, the gene expression reciprocity between NF-κB and MITF in melanoma and a transition between phenotypes MITF-Mhigh/NF-κBlow and MITF-Mlow/NF-κBhigh as a part of melanoma plasticity in response to therapies targeting the BRAF/MEK/ERK pathway have been proposed [37]. This evidence concerns the gene BRAF and melanoma.