To conclude, the association between the variant XRCC1 and schizophrenia, as depicted in the present study, appears to be the rule at least in the context of (Indian) Tamil population, inasmuch as the mutant 399Gln is seen significantly prevalent in patients (evident from the genotype analysis), to impart deleterious influence (judged from the present in silico predictive mutational analysis). The gene discussed is XRCC1; the disease is schizophrenia.