The restoration of miR-497 may represent a novel and feasible therapeutic approach to treat high-risk NB by downregulating the expression of key proteins involved in DDR such as the cell cycle regulators WEE1 and CHEK1, cell growth and survival, AKT3 and BCL2 and the vascular permeability regulator VEGFA. The gene discussed is AKT3; the disease is neuroblastoma.