Ins2-deficient (Ins2KO) NOD mice develop diabetes at an accelerated rate [28–30], as do HLA-A∗02:01-transgenic Ins2KO NOD mice [28], and both Ins2-deficient strains have increased insulin-specific islet-infiltrating CD8 T cells compared to their wild-type (WT) counterparts [28]. The gene discussed is INS; the disease is diabetes mellitus.