Comparisons of possible differences in RHR in the presence or absence of the treatment with beta-blockers, renin-angiotensin-aldosterone system blockers (i.e., sartans or angiotensin 1 receptor, 2 blockers), or other antihypertensive therapy (i.e., diuretics, Ca-blockers, and central antihypertensive drugs) revealed no statistically significant differences in the whole group or any of the CVD-b+/− or DKD-b+/− subgroups (all P > 0.05, Mann-Whitney test). The gene discussed is REN; the disease is diabetic kidney disease.