In our study the optimum cut-point of hs-CRP of 2.5 mg/L (23.6 nmol/L) in women and 1.8 mg/L (16.9 nmol/L) in men for FPG ≥126 mg/dL (7.0 mmol/L) or higher was capable of defining the new DM with a 60% sensitivity and 57% specificity in both genders. The gene discussed is CRP; the disease is diabetes mellitus.