In addition, parallel elevated expression of POU5F1 and Nanog in lung adenocarcinoma (LAC) increases the percentage of CD133-expressing subpopulation, enhances drug resistance, and promotes epithelial-mesenchymal transition (EMT); coexpression also activates Slug and enhances the tumor-initiating capability of LAC [28, 29]. Here, POU5F1 is linked to lung adenocarcinoma.