HMGB1 and liver disorder: For this purpose, various serum biomarkers have been proposed, such as alanine aminotransferase (ALT), sorbitol dehydrogenase (SDH), glutathione S-transferase (GSTα), GLDH, microRNAs, CK-18, and HMGB-1, but these are not specific of DILI or liver disease [48].