RHOA and melanoma: Thus, taking advantage of the well-known roles of RhoA (and other GTPases) in the regulation of actin polymerization and in the metastasis of many types of aggressive tumors [13, 15, 16], including melanomas [11], and considering that the mutagenic effects of UV radiation on melanocytes and keratinocytes trigger metastasis [12, 41], we explored the potential cross talk between the small GTPase RhoA, UV damage and melanoma cell migration, invasion, proliferation, and DNA repair.