We have found a statistically significant correlation between variant genotypes for GPX1 Pro198Leu, MnSOD Ala16Val, GSTP1 Ile105Val, and GSTM1 null genotype and AML in our study (p = 0.004, OR = 10.33, and 95% CI: 2.12–50.26). The gene discussed is GPX1; the disease is acute myeloid leukemia.