A positive association was observed between combined variant (heterozygous + homozygous) genotype of CAT, GPX1, MnSOD, and GSTP1 and null genotype for GSTM1 and AML risk (p = 0.017, OR = 7.34, and 95% CI: 1.43–37.67). This evidence concerns the gene SOD2 and acute myeloid leukemia.