To the best of our knowledge, even though the role of oxidative stress and GSTM1, GSTT1, GSTP1, CAT, and GPX1 as well as MnSOD2 in the pathogenesis of cancer have been previously investigated, no studies on the association of all these six polymorphisms with acute myeloid leukemia have been previously published. Here, GPX1 is linked to acute myeloid leukemia.