Piechota et al. indicate that ET-1 levels are correlated with other parameters of sepsis such as C-reactive protein, procalcitonin, or natriuretic propeptide [19], implying that ET-1 is involved in pathogenesis of sepsis and blood levels of ET-1 may serve as a biomarker of severity of sepsis [20, 21]. The gene discussed is EDN1; the disease is Sepsis.