Other biomarkers of T2D and pre-diabetes have been previously associated with methylation at ABCG1, TXNIP, and CPT1A, including 3-methyl-2-oxovalerate [33], glycine [19], several lipid traits, including phosphatidylcholines (PCs) [48], chylomicrons, and their remnants, very-low-density lipoprotein (VLDL) and IDL cholesterol particles [38]. The gene discussed is TXNIP; the disease is type 2 diabetes mellitus.