Indeed genetic deletion of mPGES-1 in MMTV/NDL mice, which are genetically predisposed to the development of HER2/neu breast cancer, showed reduced incidence of mammary tumours, reduced levels of PGE2 and VEGF-A expression, and lower levels of angiogenesis (measured as microvessel density) [47]. This evidence concerns the gene ERBB2 and breast carcinoma.