For example, in contrast with control mice, FABP4-deficient mice did not develop insulin resistance or diabetes in diet-induced obesity mode [32] and Fabp4 mRNA expression in circulating leucocytes isolated from Apoe−/− (apolipoprotein E-null) mice was correlated with atherosclerotic lesion size [33]. This evidence concerns the gene FABP4 and obesity due to melanocortin 4 receptor deficiency.