To study this, we correlated the fraction of epigenetic alterations at hypervariable DVMC loci in each normal-adjacent sample to a range of clinical characteristics of the matched tumours, including estrogen receptor (ER) progesterone receptor (PR) human epidermal growth factor receptor 2 (HER2) status, as well as age, tumour size, KI67, stage, grade, nodal and menopausal status. Here, ESR1 is linked to neoplasm.