Epigenetically, similar to cancers of other tissues, HCCs are characterized by hypomethylation of repetitive sequences, associated with genomic instability, and aberrant DNA methylation of tumor-suppressor genes, such as RASSF1A, p16, SFRP1, GADD45A, and p15 [18, 97, 98]. The gene discussed is RASSF1; the disease is cancer.