Hyperglycemia has been reported to increase the endothelial expression of the proinflammatory proteins intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1, and to decrease production of nitric oxide, all through activation of the water channel protein aquaporin (AQP)1 [11]. The gene discussed is AQP1; the disease is Hyperglycemia.