Furthermore, our findings on the role of IL15-driven NK cell-mediated inhibition of tumor growth are in accordance with our previous report using the DSS/AOM model of colitis-associated colon carcinogenesis34 and the findings that IL15 induces very densely granulated NK cells that can eliminate large established solid tumors in the absence of T and B cells35. The gene discussed is IL15; the disease is infectious otitis media.