LRP2 and Donnai-Barrow syndrome: Furthermore, resemblance of the phenotype of individuals with a STRA6 mutation (Mathew-Woods syndrome) with individuals with an LRP2 mutation (Donnai-Barrow syndrome) is obvious, as is the resemblance of a zebrafish model in which STRA6 function is disrupted (Isken et al., 2008; Scherz et al., 2008; Segel et al., 2009) with the Lrp2 knockout mouse.