Based on the range of cardiovascular abnormalities found in Lrp2 knockout mice, together with the existence of a human phenotype (Donnai-Barrow syndrome) that includes cardiac anomalies resembling those seen in the Lrp2 knockout mouse, we propose that LRP2 also plays an important role in cardiogenesis in humans, thereby regulating the development of multiple cardiac structures such as the OFT and the cardiac septa by orchestrating the migration of both the SHF and the NCCs. The gene discussed is LRP2; the disease is Donnai-Barrow syndrome.