A combination of 5 markers, i.e. GGT, ALT, bilirubin, albumin, and thrombocytes, were the most discriminatory between CLD and CIR with a sensitivity and specificity of 0.71 and 0.84, respectively, and an AUC of 0.81 (95% confidence interval: 0.77–0.91) (Fig. 2a). This evidence concerns the gene GPT and congenital secretory chloride diarrhea 1.