INS and type 2 diabetes mellitus: This study also expands upon the phenotyping of the carriers of this allele in that we were able to examine association of ANGPTL8 p.Q121X with a diagnosis of type 2 diabetes and with fasting insulin levels, and to ask a targeted hypothesis that may not reach an exome chip-wide significance level (p < 3 × 10−7 for fasting glucose and p < 4.5 × 10−7 for type 2 diabetes) as was explored in Wessel, et al [10].