CD274 and neoplasm: Nonetheless, we injected either control (LacZ-expressing) or Ciita/MHC-II+ B16 cells (ranging from 10 to 30% MHC-II+ at the time of injection) into the flank of C57/Bl6 mice and monitored tumour growth and survival with either IgG (isotype) control or anti-PD-L1 mAB, given twice weekly, beginning on day +1 following tumour-cell challenge.