Of the genes found to be differentially expressed in the hypothalami of ISIAH and WAG rats, 16 genes are annotated in the Rat Genome Database (RGD) as associated with hypertension, and two additional DEGs (P2rx4, and Sult1a1) were related to the regulation of BP according to the Database for Annotation, Visualization and Integrated Discovery (DAVID) tool. The gene discussed is P2RX4; the disease is Hypertension.