SLC22A12 and gout: The URAT1 nonfunctional variants (R90H and W258X) were not observed in any gout cases (n = 1,993), while R90H heterozygotes (G/A), W258X heterozygotes (G/A) and W258X homozygotes (A/A) were observed in 22, 150 and 2 subjects, respectively, among 2,499 control subjects (P = 8.3 × 10−46; Table 1).