To evaluate the behavioral consequences of IFN-α injection, wild-type male Balb/c mice were intraperitoneally injected with Human recombinant IFN-α-2b (hIFN-α-2b) (n = 15) or Phosphate Buffer Solution (PBS) (n = 15) for 10 days, and then depression-like behavioral profiles of the mice were assayed using FST and TST. The gene discussed is IFNA2; the disease is depressive symptom measurement.