ERBB2 and neoplasm: Both cell lines have been derived from patient primary tumors before treatment and are considered true IBC-like primary cell models.25 In addition, we also used two isotype-matched, multidrug-resistant variants (rSUM149 and rSUM190), which we have previously characterized and identified to exhibit resistance to apoptosis-inducing agents because of stress-mediated XIAP induction.16, 20 We co-cultured these tumor cells with human peripheral blood mononuclear cells (PBMCs) with and without addition of the monoclonal antibodies, cetuximab, which binds to EGFR, or trastuzumab, which binds to HER2.