Recently, Heinig et al. provided a clarifying dissection of the biological and molecular mechanisms underlying CLL cells homing to the LN.82 By crossing TCL1-tg with Cxcr5−/− mice, these authors demonstrated this receptor to be indispensable for recruitment and proliferation of CLL cells into the germinal center mediated by CXCL13-expressing follicular dendritic cells (FDCs). The gene discussed is CXCL13; the disease is B-cell chronic lymphocytic leukemia.