NFKB1 and B-cell chronic lymphocytic leukemia: The protective signal of BAFF is partly mediated by the NFkB pathway, also activated by TCL1.83 Similar results come from TCL1/APRIL double-tg.84 APRIL effects on CLL cells mainly rely on CD267/TACI TNF-receptor member and this is of therapeutic relevance as selective targeting of APRIL-TACI interaction may inhibit leukemic cells survival without affecting normal B-cells carrying another TNF-receptor member, namely CD269/BCMA.84