Taken together, our results indicate that the CJ-induced repression of mutant Notch1 re-activates the apoptotic machinery in T-ALL cells and strengthen the rationale for the use of SERCA inhibitors in the treatment of Notch1 mutant T-ALL, and probably of those cancers with mutant Notch1. This evidence concerns the gene NOTCH1 and acute lymphoblastic leukemia.