However, γ-secretase inhibitors induced only little apoptosis in human T-ALL,12 and exhibited strong cytotoxic effects in the gastrointestinal tract owing to inhibiting both mutant and wild-type Notch, thus limiting the use of this approach for cancer therapy as single agents.13, 14 By contrast, a recent report from Roti et al. showed that small molecule inhibitors of the sarcoendoplasmatic reticulum calcium ATPase (SERCA pump) are capable of preferentially inhibit mutant Notch1 activation, without gastrointestinal side-effects.15 The gene discussed is NOTCH1; the disease is acute lymphoblastic leukemia.