MCU and acute lymphoblastic leukemia: Previous studies have shown that mitochondria can buffer excess calcium released from IP3R through the mitochondrial calcium uniporter (mCU).24, 25 To study the impact of the IP3R and mCU on ROS production, T-ALL cells were pretreated with 2-APB or with the mCU inhibitor KB-R7943.26 CCRF-CEM and Jurkat cells treated with 2-APB showed a complete inhibition of CJ-induced ROS, whereas CEM-ADR5000 only exhibited a small but significant decrease.