New insight into the potential application of n-3 PUFAs in breast cancer treatment was also provided by a recent investigation in MCF-7 and T47D breast cancer cells, showing that DHA and EPA could shift the pro-survival estrogen signal to a pro-apoptotic effect by increasing the G protein coupled estrogen receptor 1-cyclic adenosine monophosphate-protein kinase A (GPER1-cAMP-PKA) signaling response, blunting EGFR, Erk 1/2 and AKT activity [121]. This evidence concerns the gene GPER1 and breast cancer.