We take into consideration different possible actions by n-3 PUFAs, such as the displacement of lipid raft associated onco-proteins as well as the modulation of different survival signaling pathways in tumor cells, including Wnt/β-catenin, MAPK/Erk, PI3K/Akt/mTOR, JAK-STAT and NF-κB pathways. The gene discussed is AKT1; the disease is neoplasm.