Finally, in prostate cancer (PC3 and LNCaP) cells, growth suppression by DHA was due to changes in cell plasma membrane phospholipid content, leading to the alteration of phosphatidylinositol phosphates (PIPs) content, PI(3,4,5)P3 (PIP3) and Akt localization, inhibition of Akt phosphorylation and thus of the AKT survival signaling pathway [123]. Here, AKT1 is linked to Familial prostate cancer.