On the other hand, concerning DHA metabolites, Gleissman et al. [138] showed that the cytotoxic action exerted by DHA in neuroblastoma cells was related to its conversion by 15-LOX and, at much lower degree by autoxidation, to 17-hydroxydocosahexaenoic acid (17-HDHA), via 17-hydroxyperoxydocosahexaenoic acid (17-HPDHA), a compound with significant cytotoxicity potency compared to DHA. Here, ALOX15 is linked to neuroblastoma.