EGFR and breast cancer: In 2007, Schley and coworkers [116] showed that apoptosis induced by a combination of EPA and DHA in MDA-MB-231 breast cancer cells was due to changes in lipid raft composition, leading to a decrease of EGFR levels as well as an increase of EGFR and p38 mitogen-activated protein kinase (MAPK) phosphorylation.