Suppression of tumor cell growth by n-3 PUFAs has been confirmed in vivo, in pre-clinical studies using cancer animal models mainly rapresented by transgenic “fat-1” mice (bearing the Caenorhabditis elegans “n-3 desaturase” gene able to convert n-6 to n-3 PUFAs, resulting thus in elevated n-3 PUFAs tissue content) and xenograft nude mice implanted with different tumor cell types [13,22,24,41,86,87,88,89]. Here, FAT1 is linked to neoplasm.