It was shown that EPA and DHA induced apoptosis in MDA-MB-231 breast cancer cells in vitro [128,129] and in a xenograft animal model [129] by the inhibition of the survival Akt/NF-κB signaling pathway, due to the inactivation of PI3K, through increased PTEN expression by n-3 PUFAs. Here, AKT1 is linked to breast carcinoma.