Different studies in colon cancer (LS-174, HT-29, Caco-2 and COLO 201) cell lines showed that dietary FO [103] or DHA [104,105] modified the expression of Bcl-2 family proteins by increasing the levels of the pro-apoptotic proteins Bak and Bcl-xS and decreasing those of the anti-apoptotic proteins Bcl-2 and Bcl-xL. This evidence concerns the gene BCL2 and malignant colon neoplasm.