Similarly, a reduction of EGFR activation was observed in EPA- or DHA-induced apoptosis in breast cancer (MDA-MB-231 and MCF-7) cells, associated to a reduction of Bcl2 and caspase-8 expression; moreover, DHA (probably related to its better capability to change lipid raft properties), but not EPA, also slightly reduced EGFR concentration [118]. This evidence concerns the gene CASP8 and breast carcinoma.