EGFR and cancer: In contrast with these results, in three different (A549 lung, WiDr colon and MDA-MB-231 breast) cancer cell models it was found that DHA-induced apoptosis was caused by the exclusion of EGFR from caveolin-rich lipid raft fractions, resulting in a decreased association of Ras with Sos1 and the subsequent downregulation of Erk signaling; these data were confirmed in vivo, using xenograft athymic mice implanted with A549 cells [117].