Ravacci [43], Mason [120] and coworkers showed that DHA induced apoptosis in transformed human mammary epithelial (HB4aC5.2) cells and in breast cancer (BT-474) cells, respectively, by the deplacement of HER-2 from lipid rafts and the decrease of Akt and ERK1/2 activation; no effects were observed in related untransformed (HB4a) cells. This evidence concerns the gene MAPK3 and breast carcinoma.