A very recent work by Rescigno et al. [134] demonstrated that DHA-induced apoptosis in aggressive SK-BR-3 breast cancer cells reduced both ERK1/2 and STAT3 phosphorylation; interestingly, DHA only arrested cell cycle progression of non-tumor MCF-10A breast cells, activating p21Waf1/Cip1 and p53. Here, STAT3 is linked to neoplasm.