BNC1 and hepatocellular carcinoma: Consistent with the results in HCC cell lines, both BNC1 and BNC2 mRNA expression levels in tumor tissues were statistically lower than that in corresponding non-tumor tissues (p < 0.0001 and p = 0.0315, respectively), as well as that in normal liver tissues (p = 0.0039 and p = 0.0299, respectively) (Figure 1B).