As Nrf2 is overexpressed in pancreatic cancer and little is known about xCT and especially CTH regulation in tumor, further study is required to clarify how PTGR2/15-keto-PGE2 specifically regulates CTH and xCT expression, whether directly through oxidative stress-related transcriptional factors or through their upstream regulators. This evidence concerns the gene CTH and pancreatic neoplasm.