SLC7A11 and cancer: It is without doubt that PPARγ is an important player in cancer biology, and although our data suggested a PPARγ-independent inhibition of xCT and CTH that lead to induced ROS and apoptosis by 15-keto-PGE2, we cannot completely rule out the possibility of PPARγ-dependent function by 15-keto-PGE2 in our study.