As Nrf2 is overexpressed in pancreatic cancer and little is known about xCT and especially CTH regulation in tumor, further study is required to clarify how PTGR2/15-keto-PGE2 specifically regulates CTH and xCT expression, whether directly through oxidative stress-related transcriptional factors or through their upstream regulators. The gene discussed is SLC7A11; the disease is familial pancreatic carcinoma.