The downstream signaling of MORC4 activation in pancreatitis needs exploration using experimental models but a protein-protein interaction database (Protein Interaction Network Analysis; PINA) [27] suggests its interaction with AMPKa1, GEMIN4, HECW2, SKIL, STAT3 and UBC, and downstream regulation of all/either of these might be pathophysiologically relevant. This evidence concerns the gene PRKAA1 and pancreatitis.