MCPH1 and breast cancer: When comparing MCPH1 c.904_916del allele’s frequency in the currently analyzed breast cancer cohort to that reported in ExAC Finns, the statistical evidence for cancer association is even more significant: for familial cohort P = 0.001 (OR 7.3, 95% CI 2.7–20.3), for unselected cohort P = 0.003 (OR 2.9, 95% CI 1.4–5.8), and for all breast cancer cases P = 0.0004 (OR 3.2 and 95% CI 1.7–6.2).