SFN has been shown to increase cytotoxicity of NK cells in the context of prostate carcinogenesis inhibition in mice [12], to augment NK cells cytotoxicity in tumor-bearing BALB/c mice [13] and to induce NKG2D ligands in human cancer cell lines and thus enhance susceptibility of cancer cells to NK cell mediated lysis [24]. The gene discussed is KLRK1; the disease is cancer.