Our data demonstrated that TFAM knockdown increased both the accumulation of cellular and mitochondrial ROS and JNK/p38 MAPK phosphorylation, which indicated that downregulation of TFAM results in the inhibition of NSCLC cell proliferation through ROS-mediated JNK and p38 MAPK activation. This evidence concerns the gene MAPK8 and non-small cell lung carcinoma.