MUC16 and ovarian cancer: Data from the multimodal arm of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS), which used a time-series algorithm to interpret serum CA125 (the Risk of Ovarian Cancer Algorithm (ROCA)) as a first line test followed by TVS as a second line test, has shown encouraging sensitivity and specificity of this approach on both the prevalence and incidence screening [8, 9].