If altered stress reactivity in Gabrd−/− mothers plays a role in the impact of maternal depression-like behaviors on offspring development, we hypothesized that inhibiting the stress response in the mother with the corticotropin-releasing hormone (CRH) antagonist, Antalarmin, would decrease the anxiety- and depression-like behaviors in the juvenile offspring (Figure 5(a)). This evidence concerns the gene CRH and depressive disorder.