The total number of bolus insulin units taken by patients with type 1 and type 2 diabetes mellitus did not change during the study (20.3 ± 6.5 units and 19.9 ± 5.7 units at baseline to 19.4 ± 7.1 units and 20.1 ± 5.5 units at week 12, 19.0 ± 7.3 units and 20.0 ± 5.6 units at week 24, respectively). The gene discussed is INS; the disease is diabetes mellitus.